His love of motorcycles began when he was two years old. He almost rode a motorcycle before learning to walk.

He made his Grand Prix debut in 2006 when he became the youngest person to score a point in a GP, eight days after his 15th birthday. Today Pol is the youngest rider to score in a World Championship event.

Before winning the Moto2 championship in 2013, he finished second in 2012 and third in 2010. In 2015 he won the Suzuka 8-hours champion title competing for the Yamaha team.

In mid-2016 he signed for KTM. During his first season at KTM, his renewal for 2018 was announced along with his partner Bradley Smith. During the Czech Republic GP, he suffered a fall during the warm up lap that caused a fracture of his left clavicle. Weeks later, he fractured that same clavicle again during the Aragón GP.

In his second season at KTM and his fifth overall in MotoGP he achieved his first podium finish, finishing third at the Valencia GP. For the 2019 season he continues with KTM. In 2020 Honda Racing Corporation made public the signing of Pol Espargaró Villà for the 2021 season. In the fifth round of the 2020 Championship, he achieved a pole position in the Styrian Grand Prix. After leading the last laps, Miguel Oliveira and Jack Miller overtook him in the last corners, finishing in third position. Also, he got the fastest lap on the track.

125cc World Championship debut with Derbi

4th place in Jerez and two 5th places at the Circuit de Catalunya, his home, and at Assen. First podium at Estoril in 2007.

Proclaimed Moto2 World Champion

He wins the title of champion of the Suzuka 8-hours racing for the official Yamaha team.